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. 2012 Jan;105(1):132–140. doi: 10.1016/j.ymgme.2011.09.033

Table 1.

Equilibrium dissociation constants for PLP (KD(PLP)) and optical activity of AGT-Ma, AGT-Mi and pathogenic variants.

Enzymatic species KD(PLP) (μM) Optical activity
AGT-Ma 0.27 ± 0.03a 97 mdeg/Abs 420 nma
AGT-Mi 0.26 ± 0.02b 97 mdeg/Abs 420 nmb
W108R-Mi 96 ± 19 4.73 mdeg/Abs 434 nm
S158L-Ma 272 ± 47 45 mdeg/Abs 430 nm
G161S-Mi 0.46 ± 0.07 66 medeg/Abs 430 nm
G161C-Mi 0.56 ± 0.09 57 mdeg/Abs 414 nm
D183N-Ma 2.1 ± 0.1 84 mdeg/Abs 430 nm
S187F-Ma < 0.01 103 mdeg/Abs 414 nm
S218L-Ma 24.2 ± 0.1 31 mdeg/Abs 428 nm
P319L-Ma 0.19 ± 0.04 88 mdeg/Abs 420 nm
G350D-Mi 0.031 ± 0.005 88 mdeg/Abs 420 nm
a

From Cellini B. et al. [18].

b

From Cellini B. et al. [22].