Fig. 2.

Overexpression of mLRP2 in PDAPP mice increased soluble Aβ in an age-dependent manner. (A) Carbonate-soluble Aβ levels were increased in both hippocampus and cortex of aged PDAPP/LRP⁺ mice compared to littermate PDAPP/LRP^– controls. (B) Insoluble Aβ level was also increased in the cortex but not in the hippocampus of aged PDAPP/LRP⁺ mice. Neither the percentage of hippocampal area covered by Aβ plaques (C) nor that of thioflavine S-positive plaques (D) differed between PDAPP/LRP⁺ and PDAPP/LRP^– mice. *, Statistically significant differences by ANOVA.