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. 2011 Jul 1;1(3):186–194. doi: 10.4161/spmg.1.3.17760

Figure 2.

Figure 2

c-kit gene and Kit structure. The c-kit DNA is 5,150 bp in length, consists of 21 exons and encodes a 150 KDa full-length protein with 979 amino acids. Exons 1–10 encode the extracellular components with 5 Ig-like domains and the signal sequences. Exon 11 encodes the transmembrane segment. Exons 12–20 encodes the intercellular segments including the juxtamembrane segment, proximal kinase domain, kinase insert domain and distal kinase domain. Exon 21 encodes the C-terminal tail. Truncated mRNA from intron 16 to exon 21 encodes the TR-Kit.