Fig. 1.

Differential sensitivity of the proliferation of LNCaP and PC-3 prostate cancer cells to anti-calmodulin W-7. Proliferation of androgen-sensitive LNCaP (•) and androgen-independent PC3 (▪) prostate cancer cells was assessed by [³H]thymidine incorporation. Cells were treated with or without the indicated concentrations of W-7 for 48 h before pulse labeling for 30 min with [³H]thymidine. Data are the average of duplicate determinations. There was <10% variation between duplicate determinations.