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. 2011 Dec 1;119(4):957–966. doi: 10.1182/blood-2011-09-377630

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© 2012 by The American Society of Hematology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Expression of hFVII in young rhesus monkeys following fetal administration of vector supernatant and readministration postnatally. (A) Plasma human FVII levels in young rhesus monkeys following administration of 4 × 10¹¹ vg/kg scAAV5-LP1-hFVII-coop prenatally and scAAV8-LP1-hFVII-coop at 1 year postnatal age. (B) Anti-AAV5 IgG levels in plasma after fetal administration of AAV5 LP1 hFVII coop. (C) Anti-AAV8 IgG levels following administration of scAAV8-LP1-hFVII-coop (second administration of vector) in monkeys at 1 year postnatal age.