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. 2003 Dec 26;101(2):540–545. doi: 10.1073/pnas.2536759100

Fig. 3.

Fig. 3.

Effects of SAHA on regulators of apoptosis and sensitivity to caspase-dependent drug-induced apoptosis. (A) Functional clustering analysis for changes in gene expression of regulators of apoptosis. (B) p53 DNA-binding ELISA confirms that SAHA treatment (1 μM0–24 h) induces activation of p53. (C and D) MTT assays confirm that SAHA pretreatment (50 nM for 24 h) enhances sensitivity of MM-1S cells to dexamethasone (0.1 μM for an additional 48 h) (C) or the immunomodulatory thalidomide derivative IMID-1 (CC-4047) (0.01 μM for 48 h) (D).