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Regulation of angiogenic-regulatory genes by the COX-2 pathway. RNA was isolated from nontumor (NT) and tumor (T) regions in multiparous COX-2 mice (A) and from nontreated (N) and indomethacin-treated (I) multiparous COX-2 mice (B). Expression of VEGF, Ang1, Ang2, Flt, Flk, Tie-1, and Tie-2 was analyzed by RT-PCR analysis.
