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. Author manuscript; available in PMC: 2012 Sep 12.
Published in final edited form as: ACS Comb Sci. 2011 Aug 25;13(5):511–517. doi: 10.1021/co200093c

Table 1.

Optimization of one-pot click/aza-Michael reaction conditions

graphic file with name nihms321334u1.jpg
entrya azide {G} (equiv.) amine 6 (equiv.) CuI (mol %) DBU (mol%) yield (%)
1 2 2 10 mol% 10 mol% 62 %
2 2 2 30 mol% 10 mol% 96 %
3 1 1 30 mol% 10 mol% 78 %
4 2 1.2 30 mol % 10 mol% 95 %
5 2 1.2 30 mol% 10 mol% 96 %
a

Reactions carried out utilizing 2 (50 mg, 0.32 mmol, 1 equiv.) in 0.5 M EtOH at 60 °C for 12 hrs.