Table 2.
12-Member validation library probing reaction scope
| sultama | purity (%)b |
yield (%)b |
quantity (mg) |
|---|---|---|---|
| 5{2} | 83 | 45 | 69.0 |
| 5{4} | 97 | 51 | 77.6 |
| 5{5} | 99 | 30 | 42.5 |
| 5{6} | 97 | 44 | 66.9 |
| 5{7} | 74 | 36 | 69.0 |
| 5{8} | 91 | 51 | 71.5 |
| 6{4} | 93 | 32 | 49.0 |
| 6{5} | 97 | 47 | 71.9 |
| 6{6} | 98 | 62 | 94.9 |
| 6{8} | 93 | 37 | 54.3 |
| 21{6} | 96 | 51 | 90.3 |
| 33{6} | 94 | 50 | 93.2 |
a
Reaction conditions: Benzothiaoxazepine-1,1-dioxide 1-12 (1 equiv., 0.434 mmol), dry DMSO (434 μL, 1M), DBU (7 μL, 10 mol%) and amine (5 equiv.).
b
Purified by automated preparative reverse phase HPLC (detected by mass spectroscopy); purity was assessed by HPLC.