Table 3.
Entry | R1CO2H | R2NH2 | Yield (%)c | Purity (%)b |
---|---|---|---|---|
1 | BnCO2H | BnNH2 | 95 | >95 |
2 | C9H19CO2H | BnNH2 | 93 | >95 |
3 | p-TolCO2H | iPrNH2 | 92 | >95 |
4 | P-TolCO2H | C5H8NH | 93 | >95 |
5 | 4-OMe-3-MeBnCO2H | C5H8NH | 96 | >95 |
All reactions were carried out on 0.164 mmol scale, with addition of 2.0 equivalents of 3 unless stated otherwise.
Purity by GC and confirmed by 1H NMR.
Yields were calculated from pure products after purification via elution through a silica SPE.