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. 2012 Feb 3;7(2):e31254. doi: 10.1371/journal.pone.0031254

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Garbuzova-Davis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Kaplan-Meier survival curves for G93A mice receiving 2.5×10⁶ (Gr 1) or 1×10⁶ (Gr 2) cells at symptomatic disease stage and 1×10⁶ (Gr 3) cells pre-symptomatically. Control group was Media-injected mice (Gr 4). Significant () increases in survival were determined in mice receiving 1×10⁶ cells at pre-symptomatic stage (p = 0.0015) and 2.5×10⁶ cells at symptomatic stage (p = 0.0022) vs. the Media-injected group. Survival of the mouse group receiving 1×10⁶ cells pre-symptomatically tended towards significance compared to survival of mice receiving same cell dose at symptomatic stage (p = 0.0595). (B) Percentages of surviving mice within age ranges. Media-injected animals survived no longer than 19.5 weeks, whereas 30% of mice receiving 2.5×10⁶ (Gr 1, symptomatic) or 1×10⁶ cells (Gr 3, pre-symptomatic) and 14.3% mice administered with 1×10⁶ cells (Gr 2) at symptomatic stage survived more than 140 days and 10% of mice from Gr 3 (1×10⁶ cells, pre-symptomatic) were alive for more than 150 days.

Inline graphic — (A) Kaplan-Meier survival curves for G93A mice receiving 2.5×10⁶ (Gr 1) or 1×10⁶ (Gr 2) cells at symptomatic disease stage and 1×10⁶ (Gr 3) cells pre-symptomatically. Control group was Media-injected mice (Gr 4). Significant () increases in survival were determined in mice receiving 1×10⁶ cells at pre-symptomatic stage (p = 0.0015) and 2.5×10⁶ cells at symptomatic stage (p = 0.0022) vs. the Media-injected group. Survival of the mouse group receiving 1×10⁶ cells pre-symptomatically tended towards significance compared to survival of mice receiving same cell dose at symptomatic stage (p = 0.0595). (B) Percentages of surviving mice within age ranges. Media-injected animals survived no longer than 19.5 weeks, whereas 30% of mice receiving 2.5×10⁶ (Gr 1, symptomatic) or 1×10⁶ cells (Gr 3, pre-symptomatic) and 14.3% mice administered with 1×10⁶ cells (Gr 2) at symptomatic stage survived more than 140 days and 10% of mice from Gr 3 (1×10⁶ cells, pre-symptomatic) were alive for more than 150 days.