Figure 2. Evaluations of disease progression in G93A mice through Kaplan-Meier analysis.

(A) Time elapsed until animals lost 15% of their maximum body weight. Mice receiving 1×10⁶ cells pre-symptomatically (Gr 3) significantly () maintained body weight vs. Media (Gr 4) mice. A similar trend was observed in mice treated with 2.5×10⁶ cells (Gr 1) beginning at symptomatic disease stage. (B) Time elapsed until hindlimb extension scores deteriorated by 70% of the initial score. The Gr 1 and Gr 3 mice significantly () delayed decline of hindlimb extension compared to Gr 4 mice. A significant difference was also detected between Gr 3 and Gr 2 mice receiving 1×10⁶ cells at pre-symptomatic or symptomatic stage of disease, respectively. (C) Time elapsed until muscle strength decreased by 70% from the maximum value. Mice from Gr 3 significantly () delayed muscle strength losses vs. Gr 4. Gr 1 mice tended to maintain muscle strength post-transplant. (D) Time elapsed until rotarod latency decreased by 70% of the maximum value. Only mice from Gr 3 performed better on the rotarod than other cell-treated mice and tended towards significance () taking more time to decrease latency by over 70% of the maximum value compared to Gr 4.