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. 2012 Feb 3;7(2):e31254. doi: 10.1371/journal.pone.0031254

Figure 7. Characteristics of astrocytes in the spinal cord of G93A mice.

Figure 7

Astrocyte densities were measured in the cervical (A) and lumbar (B) ventral horns of G93A mice at 17 weeks of age and at end-stage of disease. Astrocytic densities were significantly (p<0.001) higher in Media-injected mice (Gr 4) at 17 weeks of age and at end-stage of disease vs. controls (Gr 5) of the same ages. Significant (p<0.001) decrease in the number of astrocytes was determined in cell-treated G93A mice compared to Media mice. No significant statistical differences were detected between the cell-treated groups. Higher number of reactive astrocytes was observed in Media-injected mice at 17 weeks of age and at end-stage disease compared to cell-treated animals. ***p<0.001. (C) Immunohistochemical staining of astrocytes in the lumbar spinal cord of G93A mice at 17 weeks of age. Anti-GFAP antibody staining showed low astrocyte density in controls (a) and astrocytosis in Media-treated animals (b). Considerably decreased actrocytic density was observed in mice from Gr 1 (c), Gr 2 (d), and Gr 3 (e). Astrocyte cell reactivity was also reduced in cell-treated mice vs. Media-injected mice (inserts in a–e). Scale bar: a–e is 200 µm; in a–e inserts is 25 µm.