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. 2012 Feb 3;7(2):e31004. doi: 10.1371/journal.pone.0031004

Figure 7. Chloroquine and hydroxychloroquine decrease CXCL12-mediated proliferation in pancreatic cancer cell lines.

Figure 7

(A) PANC-1, (B) Hs-766T, and (C) MIAPaCa-2 cells were pretreated with chloroquine or hydroxychloroquine (0.1 µM) for 30 minutes after which cells were exposed to CXCL12 (200 ng/ml) for 72 hours. (D) Pretreatment with chloroquine and hydroxychloroquine also triggered apoptosis and decreased CXCL12-mediated apoptosis in PANC-1 cells. The data show the mean of triplicate experiments. P-values<0.05 were considered statistically significant.