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. 2012 Jan 28;18:241–254.

Table 3. Gene ontology terms enriched by analysis of non-housekeeping human TM expressed genes (Bonferroni p≤0.01).

Category Term Gene annotation No. genes Bonferroni p-value
Biologic process
 GO:0048731
 System development
 227
 1.88E-18
Biologic process
 GO:0032502
 Developmental process
 280
 2.45E-18
Biologic process
 GO:0048856
 Anatomic structure development
 239
 4.89E-18
Biologic process
 GO:0007275
 Multicellular organismal development
 259
 2.44E-17
Biologic process
 GO:0048513
 Organ development
 177
 4.28E-15
Biologic process
 GO:0009653
 Anatomic structure morphogenesis
 134
 1.13E-13
Biologic process
 GO:0042127
 Regulation of cell proliferation
 95
 1.88E-10
Biologic process
 GO:0032501
 Multicellular organismal process
 320
 7.73E-10
Biologic process
 GO:0030198
 Extracellular matrix organization
 28
 1.08E-08
Biologic process
 GO:0051270
 Regulation of cell motion
 38
 2.41E-08
Biologic process
 GO:0007399
 Nervous system development
 109
 3.33E-07
Biologic process
 GO:0042060
 Wound healing
 36
 3.35E-07
Biologic process
 GO:0040012
 Regulation of locomotion
 36
 3.89E-07
Biologic process
 GO:0042221
 Response to chemical stimulus
 122
 5.17E-07
Biologic process
 GO:0022603
 Regulation of anatomic structure morphogenesis
 38
 1.10E-06
Biologic process
 GO:0043062
 Extracellular structure organization
 32
 1.52E-06
Biologic process
 GO:0006928
 Cell motion
 60
 2.88E-06
Biologic process
 GO:0030334
 Regulation of cell migration
 32
 3.86E-06
Biologic process
 GO:0001944
 Vasculature development
 40
 4.58E-06
Biologic process
 GO:0032879
 Regulation of localization
 70
 5.99E-06
Biologic process
 GO:0009888
 Tissue development
 74
 7.37E-06
Biologic process
 GO:0001568
 Blood vessel development
 39
 7.86E-06
Biologic process
 GO:0050793
 Regulation of developmental process
 74
 1.33E-05
Biologic process
 GO:0030154
 Cell differentiation
 141
 1.38E-05
Biologic process
 GO:0048522
 Positive regulation of cellular process
 154
 2.02E-05
Biologic process
 GO:0009887
 Organ morphogenesis
 65
 2.12E-05
Biologic process
 GO:0040017
 Positive regulation of locomotion
 23
 2.16E-05
Biologic process
 GO:0051272
 Positive regulation of cell motion
 23
 2.16E-05
Biologic process
 GO:0051239
 Regulation of multicellular organismal process
 92
 3.57E-05
Biologic process
 GO:0008284
 Positive regulation of cell proliferation
 52
 5.50E-05
Biologic process
 GO:0048869
 Cellular developmental process
 143
 6.15E-05
Biologic process
 GO:0009611
 Response to wounding
 61
 7.10E-05
Biologic process
 GO:0006950
 Response to stress
 141
 8.91E-05
Biologic process
 GO:0022008
 Neurogenesis
 66
 1.06E-04
Biologic process
 GO:0048518
 Positive regulation of biologic process
 162
 1.65E-04
Biologic process
 GO:0009605
 Response to external stimulus
 88
 1.99E-04
Biologic process
 GO:0048514
 Blood vessel morphogenesis
 33
 2.49E-04
Biologic process
 GO:0007167
 Enzyme linked receptor protein signaling pathway
 44
 4.24E-04
Biologic process
 GO:0001501
 Skeletal system development
 42
 4.53E-04
Biologic process
 GO:0048699
 Generation of neurons
 61
 4.77E-04
Biologic process
 GO:0048519
 Negative regulation of biologic process
 146
 4.87E-04
Biologic process
 GO:0030335
 Positive regulation of cell migration
 20
 5.44E-04
Biologic process
 GO:0048523
 Negative regulation of cellular process
 136
 5.95E-04
Biologic process
 GO:0007155
 Cell adhesion
 71
 6.80E-04
Biologic process
 GO:0022610
 Biologic adhesion
 71
 7.21E-04
Biologic process
 GO:0007169
 Transmembrane receptor protein tyrosine kinase signaling pathway
 33
 0.001
Biologic process
 GO:0065008
 Regulation of biologic quality
 122
 0.0015
Biologic process
 GO:0016477
 Cell migration
 37
 0.0018
Biologic process
 GO:0008285
 Negative regulation of cell proliferation
 44
 0.0019
Biologic process
 GO:0032101
 Regulation of response to external stimulus
 26
 0.0033
Biologic process
 GO:0043067
 Regulation of programmed cell death
 76
 0.0053
Biologic process
 GO:0035295
 Tube development
 31
 0.0063
Biologic process
 GO:0010941
 Regulation of cell death
 76
 0.0064
Biologic process
 GO:0042981
 Regulation of apoptosis
 75
 0.0074
Biologic process
 GO:0051674
 Localization of cell
 38
 0.0088
Biologic process
 GO:0048870
 Cell motility
 38
 0.0088
Cellular component
 GO:0044421
 Extracellular region part
 109
 7.78E-13
Cellular component
 GO:0005576
 Extracellular region
 172
 7.52E-10
Cellular component
 GO:0031012
 Extracellular matrix
 51
 7.34E-09
Cellular component
 GO:0044459
 Plasma membrane part
 179
 1.96E-08
Cellular component
 GO:0031226
 Intrinsic to plasma membrane
 114
 5.43E-08
Cellular component
 GO:0005578
 Proteinaceous extracellular matrix
 47
 6.44E-08
Cellular component
 GO:0005887
 Integral to plasma membrane
 110
 2.62E-07
Cellular component
 GO:0005615
 Extracellular space
 70
 1.51E-05
Cellular component
 GO:0005886
 Plasma membrane
 257
 2.57E-05
Cellular component
 GO:0005581
 Collagen
 13
 3.45E-05
Cellular component
 GO:0044420
 Extracellular matrix part
 23
 3.87E-05
Cellular component
 GO:0005624
 Membrane fraction
 73
 9.01E-04
Cellular component
 GO:0000267
 Cell fraction
 89
 0.0027
Cellular component
 GO:0005626
 Insoluble fraction
 73
 0.0032
Molecular function
 GO:0005515
 Protein binding
 509
 4.31E-06
Molecular function
 GO:0005102
 Receptor binding
 86
 4.26E-05
Molecular function
 GO:0005201
 Extracellular matrix structural constituent
 19
 4.31E-04
Molecular function
 GO:0008201
 Heparin binding
 20
 0.0015
Molecular function
 GO:0008083
 Growth factor activity
 25
 0.0038
Molecular function
 GO:0005539
 Glycosaminoglycan binding
 23
 0.004
Molecular function
 GO:0030247
 Polysaccharide binding
 24
 0.0059
Molecular function
 GO:0001871
 Pattern binding
 24
 0.0059
Molecular function GO:0004714 Transmembrane receptor protein tyrosine kinase activity 15 0.0084