Table 4. Distribution of genes with altered expression due to experimental manipulations among housekeeping and non-HK TM expressed genes*.
| Experimental manipulation | Reference | (No.) % HK TM genes affected by experimental manipulation* | (No.) % non- HK TM genes affected by experimental manipulation* | Statistical significance | % non-HK/% HK TM genes affected by experimental manipulation |
|---|---|---|---|---|---|
| Treatment with prostoglandin analogs |
8 |
(25) 0.57 |
(8) 0.83 |
NS (p<0.50) |
1.47 |
| TGFβ¥ treatment |
9 |
(35) 0.79 |
(49) 5.09 |
p<0.001 |
6.43 |
| Glaucoma versus non-glaucoma TM cells |
10 |
(6) 0.14 |
(5) 0.51 |
NS (p~0.10) |
3.82 |
|
PITX2 knockdown |
11 |
(11) 0.25 |
(9) 0.94 |
p~0.001 |
3.76 |
| Effect of aging on retina& | 21 | (8) 0.18 | (1) 0.10 | NS (p<0.75) | 0.56 |
*Affected genes are as reported in respective studies, and HK and non-HK genes refer to genes identified in present study; ¥ transforming growth factor β; & represents a control treatment relating to a non-TM ocular tissue; NS=not significant.