Table 5. MicroRNAs with target enrichment in functionally grouped non-HK TM genes*.
| Group no. | miRNA with enriched targets | No. target genes (No. genes in group) | Target genes | p value |
|---|---|---|---|---|
| 3 |
HSA-MIR-29A.5 |
8 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL7A1, COL11A1 |
2.85E-09 |
| 3 |
HSA-MIR-29C.5 |
8 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL7A1, COL11A1 |
5.12E-09 |
| 3 |
HSA-MIR-29B.5 |
7 (10) |
COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL7A1, COL11A1 |
3.91E-07 |
| 3 |
HSA-MIR-29A.4 |
8 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL7A1, COL11A1 |
8.04E-07 |
| 3 |
HSA-MIR-29B.4 |
8 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL7A1, COL11A1 |
9.36E-07 |
| 3 |
HSA-MIR-29C.4 |
8 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2, COL7A1, COL11A1 |
1.05E-06 |
| 3 |
HSA-LET-7A.4 |
6 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2 |
0.0014 |
| 3 |
HSA-LET-7C.4 |
6 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2 |
0.0015 |
| 3 |
HSA-LET-7B.4 |
6 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A1, COL5A2 |
0.0017 |
| 3 |
HSA-LET-7G.4 |
5 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A2 |
0.01 |
| 3 |
HSA-LET-7F.4 |
5 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A2 |
0.01 |
| 3 |
HSA-LET-7E.4 |
5 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A2 |
0.01 |
| 3 |
HSA-LET-7I.4 |
5 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A2 |
0.01 |
| 3 |
HSA-MIR-98.4 |
5 (10) |
COL1A1, COL4A1, COL4A2, COL4A5, COL5A2 |
0.01 |
| 11 |
HSA-MIR-657.4 |
5 (13) |
FKTN, UST, GALNT10, XYLT1, GLT8D2 |
0.01 |
| 13 |
HSA-MIR-517B.4 |
5 (49) |
SLC2A3, SCARA3, ORAI2, MBOAT2, C9ORF91 |
0.01 |
| 13 |
HSA-MIR-188–3P.4 |
5 (49) |
SLC7A11, FAM119B, D4S234E, FAM171A1, FAM155A |
0.03 |
| 14 |
HSA-MIR-26A.5 |
6 (33) |
CDK6, DAPK1, PDGFRA, MAP3K2, STK39, TRIB2 |
0.01 |
| 14 |
HSA-MIR-34A.5 |
5 (33) |
AXL, CDK6, EPHA4, MET, PDGFRA |
0.01 |
| 14 |
HSA-MIR-34C-5P.4 |
7 (33) |
AXL, CDK6, EPHA4, MET, PDGFRA, IKBKE, STK39 |
0.01 |
| 14 |
HSA-MIR-34A.4 |
6 (33) |
AXL, CDK6, EPHA4, MET, PDGFRA, PRKD1 |
0.01 |
| 14 |
HSA-MIR-26B.4 |
7 (33) |
CDK6, DAPK1, PDGFRA, WEE1, MAP3K2, STK39, TRIB2 |
0.02 |
| 14 |
HSA-MIR-381.4 |
7 (33) |
EPHA4, GRK5, MET, RPS6KA3, TEK, WEE1, ZAK |
0.02 |
| 14 |
HSA-MIR-449B.4 |
5 (33) |
AXL, CDK6, EPHA4, PDGFRA, IKBKE |
0.02 |
| 14 |
HSA-MIR-26A.4 |
7 (33) |
CDK6, DAPK1, PDGFRA, WEE1, MAP3K2, STK39, TRIB2 |
0.02 |
| 14 |
HSA-MIR-519C-5P.4 |
8 (33) |
AXL, CDK6, EPHA4, MYLK, PTK7, RPS6KA3, MAP3K2, ZAK |
0.02 |
| 14 |
HSA-MIR-26B.5 |
5 (33) |
CDK6, DAPK1, MAP3K2, STK39, TRIB2 |
0.02 |
| 14 |
HSA-MIR-485–3P.4 |
5 (33) |
CDK6, DAPK1, MET, MELK, TRIB2 |
0.03 |
| 14 |
HSA-MIR-323–3P.4 |
6 (33) |
DAPK1, MET, RPS6KA3, SGK1, MELK, MAP3K2 |
0.03 |
| 14 |
HSA-MIR-32.4 |
6 (33) |
AXL, CDK6, SGK1, AATK, STK39, ZAK |
0.04 |
| 18 |
HSA-MIR-124.4 |
7 (19) |
AHR, E2F3, ELF4, ETS1, MITF, PLAGL2, SOX9 |
0.01 |
| 18 |
HSA-MIR-145.4 |
5 (19) |
KLF5, ETS1, MAF, PLAGL2 SOX9 |
0.02 |
| 18 | HSA-MIR-32.4 | 5 (19) | E2F3, GATA2, MITF, SOX4, HAND1 | 0.02 |
* miRNAs identified using BioProfiling under stringent setting; gene function groups identified by classification tool of DAVID.