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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Thromb Haemost. 2012 Feb;10(2):177–188. doi: 10.1111/j.1538-7836.2011.04571.x

Table 1.

Cell-extrinsic soluble factors essential for HSC maintenance and their source in bone marrow niches

Factor Receptor Role/Function Primary Source
SCF (kit ligand) c-Kit HSC localization, survival and maintenance. Bone marrow stromal cells[130]
SDF1 CXCR4 Principal axis determining HSC/HPC localization [131].
Promotes surface integrin upregulation and HSC survival [45, 132].		 Mesenchymal stem cells [36]
Reticular cells [34]
Osteoblasts
Ang-1 Tie2 Promotes maintenance of quiescent HSCs Osteoblasts[15], endothelial cells, pericytes[133]
TPO TPO receptor (c-Mpl) Regulates stem cell quiescence [16, 134] Liver, kidney, bone marrow stroma, osteoblasts [42]
Ca2+ ions G-protein coupled Ca2+-sensing receptor Maintains localization of HSCs near the endosteal bone lining[19] Osteoclast-mediated bone degradation