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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: J Thromb Haemost. 2012 Feb;10(2):177–188. doi: 10.1111/j.1538-7836.2011.04571.x

Table 2.

Megakaryocyte-derived factors that may influence haematopoietic niches

Osteoblastic niche Osteoclastogenic promoters RANKL[135]
Osteoclastogenic inhibitors Osteoprotegerin[57, 135]
Osteoblast promoters/Mesenchymal growth factors PDGF, FGF2, TGFβ, fibronectin-binding surface integrins[56, 58]
Bone matrix proteins Osteocalcin, osteonectin, osteopontin, bone sialoprotein, BMP-2, -4 and -6. [56]
Vascular niche Proangiogenic factors VEGF, PDGF, TGFβ IGF-2, b-FGF (FGF2), hepatocyte growth factor (HGF), epidermal growth factor (EGF), SDF1 (CXCL12), Lipid mediators e.g. sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) and MMPs[68, 136]
Antiangiogenic factors TSPs, Endostatin, Plasminogen activator inhibitor (PAI) type 1, TGFβ, PF4 (CXCL4)[68, 136]
Chemokines SDF1[64, 88] (synthesized in low amounts by megakaryocytes-largely taken up from the microenvironment), PF4[137]