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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Hepatology. 2012 Apr;55(4):1182–1192. doi: 10.1002/hep.24735

Table 2. Representation of major functionally annotated groups in differentially expressed gene lists in NHB donor hepatocytes versus HB donor hepatocytes.

Gene ontology groups Cells from NHB donor liver 4h Cells from NHB donor liver 16h
Number Upregulated genes (%) Number Downregulated genes (%) Number Upregulated genes (%) Number Downregulated genes (%)
Cellular process 984 (37%) 732 (43%) 745 (47%)
Primary metabolic process 480 (28%) 595 (22%) 511 (32%)
Cellular metabolic process 485 (29%) 595 (22%) 508 (32%)
Macromolecule metabolic process 410 (24%) 512 (19%) 450 (29%)
Biological regulation 455 (17%) 361 (21%) 458 (17%) 346 (22%)
Regulation of biological process 394 (15%) 322 (19%) 390 (14%) 308 (20%)
Biopolymer metabolic process 366 (14%) 320 (19%) 380 (14%) 332 (21%)
Regulation of cellular process 345 (13%) 287 (17%) 351 (13%) 276 (17%)
Developmental process 323 (12%) 252 (15%) 316 (12%) 236 (15%)
Protein metabolic process 240 (15%)
Cellular macromolecule metabolic process 227 (14%)
Cellular protein metabolic process 221 (14%)
Cellular localization 314 (12%) 208 (12%) 326 (12%) 204 (13%)
Cellular component organization and biogenesis 279 (11%) 210 (12%) 281 (10%) 208 (13%)
Establishment of localization 271 (10%) 175 (10%) 294 (11%) 175 (11%)
Transport 263 (10%) 172 (10%) 282 (10%) 169 (11%)
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 258 (10%) 243 (14%) 265 (10%) 251 (16%)
Gene expression 234 (9%) 204 (12%) 248 (9%) 214 (14%)
Regulation of metabolic process 211 (8%) 180 (11%) 176 (11%)
Multicellular organismal development 240 (9%) 179 (11%) 229 (8%) 156 (10%)
Establishment of localization 271 (10%) 175 (10%) 294 (11%) 175 (11%)
RNA metabolic process 188 (7%) 172 (10%) 201 (7.4%) 182 (12%)
Anatomical structure development 232 (9%) 168 (10%) 238 (9%) 155 (10%)
Regulation of cellular metabolic process 193 (7%) 168 (10%) 198 (7%) 170 (11%)
Regulation of gene expression 186 (7%) 162 (10%) 178 (6.5%) 162 (10%)
Transcription 176 (6.6%) 160 (9.4%) 174 (6.4%) 158 (10%)
Others
Intracellular signaling cascade 142 (5%) 121 (7%) 161 (6%) 123 (8%)
Response to stress 105 (4%) 102 (6%) 116 (4%) 104 (7%)
Cell adhesion 103 (4%) 84 (3%)
Cell-cell signaling 90 (3%) 77 (3%) 56 (4%)
Potassium ion transport 30 (1%) 23 (1%)
Induction of programmed cell death 31 (2%) 26 (1%) 27 (2%)
Wnt receptor signaling pathway 16 (0.6%)
Calcium mediated signaling 10 (0.6%) 10 (0.4%) 9 (0.6%)