. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Arthritis Rheum. 2012 Mar;64(3):655–664. doi: 10.1002/art.33408

Table 4.

Associations of NAT-2 haplotypes with RA risk based on smoking exposure^*

	Never and < 10 pack-years
	Control haplotype frequency	RA case haplotype frequency	O.R. (95% CI)

TAA	26.0%	26.8%	1.00 (Referent)
TAG	27.5%	28.1%	1.17 (0.78 to 1.77), p = 0.45
CGA	30.4%	22.9%	0.83 (0.56 to 1.22), p = 0.34
	≥ 10 pack-years
	Control haplotype frequency	RA case haplotype frequency	O.R. (95% CI)

TAA	30.0%	23.4%	1.00 (Referent)
TAG	34.9%	29.1%	1.03 (0.41 to 2.62), p = 0.94
CGA	11.3%	25.5%	4.15 (1.55 to 11.09), p = 0.005

Single nucleotide polymorphisms comprising the haplotypes (in order) are rs9987109; rs1208; rs721399. TAA = haplotype from major alleles; ORs age- and gender-adjusted.