Table 1.
Hydrazone Crosslinked Materials
| Biomaterial | Aldehyde Component | Hydrazide Component | Application | In vivo | Ref. |
|---|---|---|---|---|---|
| Hyaluronan | HA | HA | bone tissue engineering (BMP-2 delivery) | rat | [29] |
| vocal fold (multicomponent gels with collagen) | pig | [30] | |||
| anti-inflammatory delivery (dexamethasone) | mouse | [31] | |||
| nerve blockade (bupivacaine delivery) | rat | [32] | |||
| surgical adhesion prevention, drug delivery (tPA) | rabbit | [33] | |||
| surgical adhesion prevention | rabbit | [34] | |||
| HA | BP | drug delivery (bisphosphonate) | -- | [35] | |
| HA | PVA | bone tissue engineering (BMP-2 delivery) | rat | [36] | |
| HA or PEG | HA | vocal fold regeneration | -- | [38] | |
| PEG | HA | drug delivery (anti-bacterial, anti-inflammatory) | -- | [39] | |
| DX or HA | HA | tissue regeneration, drug delivery | rat | [40] | |
| PG | ADH or PAH | cell and drug delivery | -- | [42] | |
| Alginate | PG | ADH | cell delivery | -- | [43] |
| Alg | ADH | bone tissue engineering | mouse | [44] | |
| PG | ADH | cell adhesion, tissue engineering | -- | [45] | |
| Alg | ADH | drug delivery (methotrexate, doxorubicin, mitoxantrone) | -- | [46] | |
| PG | ADH | drug delivery (daunomycin) | -- | [47] | |
| Dextran | DX | CMC | drug delivery (amphotericin) | -- | [48] |
| DX or CMC | CMD | surgical adhesion prevention | rabbit | [49] | |
| DX | ADH | ocular cell therapy | -- | [50] | |
| DX | ADH | drug delivery, tissue engineering | -- | [51] | |
| Misc. | PVA | PVA | cell delivery | -- | [37] |
| CP | ADH | drug delivery (doxorubicin) | -- | [52] |
Abbreviations: HA, hyaluronan; BP, aminomethylene-bisphosphonate; PVA, poly(vinyl alcohol); PEG, polyethylene glycol; DX, Dextran; CS, chondroitin sulfate; Alg, sodium alginate; ADH, adipic acid dihydrazide; PG, polyguluronate; CMC, carboxymethylcellulose; PAH, poly(acrylamide-co-hydrazide); CMD, carboxymethyldextran; CP, citrus pectin; tPA, tissue-type plasminogen activator; BMP-2, bone morphogenic protein 2.