Table 1.

Key players in histone and histone chaperone import. Listed are the histone chaperones, HATs, chromatin remodelers, importins and heat shock proteins discussed in detail in this review. Some histone chaperones, histones and importins are excluded for brevity.

Family	Yeast protein	Metazoan counterpart human (h) or xenopus (x)	Function	Histone preference	Notes
CAF1 complex	Cac1	p150	Histone chaperone	H3-H4
	Cac2	p60	Histone chaperone	H3-H4
	Cac3	p48/RbAp48	Histone chaperone	H3-H4	homologous to RbAp46
HAT-B complex	Hat1	HAT1	HAT enzyme	H3-H4
	Hat2	RbAp46	Chaperone-like accessory	H3-H4	homologous to RbAp48
	Hif1		Histone chaperone	H3-H4	some homology with NASP
N1/N2 family		NASP (tNASP, sNASP) (h)	Histone chaperone	H3-H4, H1	some homology with Hif1
		N1/N2 (x)	Histone chaperone	H3-H4
Nap1 family	Nap1	NAP1, NAP1L proteins	Histone chaperone	H2A/Z-H2B, H1
	Vps75	SET	Histone chaperone	H3-H4
		TSPY, TSPYL proteins	Histone chaperone
NPM family		NPM1 (nucleophosmin	Histone) chaperone	H3-H4, H1
		Nucleoplasmin (NPM2)	Histone chaperone	H2A-H2B, H1
		Nucleolin	Histone chaperone	H2A-H2B
	Asf1	ASF1a, ASF1b	Histone chaperone	H3-H4
	Rtt109	p300/CBP	HAT enzyme	H3-H4	structural homologs only
	Chz1		Histone chaperone	Htz1-H2B	HIRIP3 has Chz domain
	Rtt106		Histone chaperone	H3-H4	some homology with Daxx
		DAXX	Histone chaperone	H3.3-H4	some homology with Rtt106
		ATRX	Chromatin remondeler
		HSP90	Heat shock protein, ATPase		interacts with H3-H4 in cytoplasm
		HSC70	Heat shock protein		interacts with H3-H4 in cytoplasm
Karyopherin family	Kap60	Impα	Importin		imports Chz1, Vps75, NPM2
	Kap95	Impβ	Importin		imports Chz1, Vps75, NPM2
	Kap114 Kap123 Kap121	Imp9 Imp4 Imp5	Importin Importin Importin	H2A/Z-H2B H3-H4 H2A-H2B, H3-H4	Imports Nap1