Skip to main content
. 2012 Jan 1;11(1):109–118. doi: 10.4161/cc.11.1.18473

Figure 6.

Figure 6

Inhibition of Rb-Raf interaction prevents proliferation and expression of E2F1 target proliferative genes in AoSMC. (A) Treatment with RRD-251 inhibits AoSMC proliferation induced by serum, TNFα and PDGF. (B and C) Treatment with RRD-251 inhibits expression of E2F target genes cdc 6, TS and cdc 25A, as seen by RT-PCR. (D) Depletion of E2F1 and E2F3 using siRNAs resulted in significant inhibition of TNFα and PDGF induced AoSMC proliferation, whereas E2F2 depletion had only a marginal effect.