FIG. 4.

Comparison of the neuron morphology of rat sensory neurons cultured with either human or rat Schwann cells. (A) Neurofilament staining of co-cultures with rat (+rSC) or human Schwann cells (+hSC) revealed a reduced neurite density in cultures with human Schwann cells. (B) Quantification of the neurite density of co-cultures with either rat or human Schwann cells. (C) Rat neurons that are co-cultured with human Schwann cells reveal smaller, shrunken perikarya (bar=100 μm). (D) Quantification of the average perikaryon diameter of rat neurons cultured with either rat or human Schwann cells. Color images available online at www.liebertonline.com/scd