Fig. 4.
Comparative effects of glibenclamide and riluzole on mortality and mBBB scores. A: Mortality was assessed in rats administered vehicle (filled squares), riluzole (empty triangles) or glibenclamide (filled circles); no animal died after day 8; 13–15 rats per group; the abscissa gives the time in days. B: Serial measurements of mBBB scores for the contralateral hindlimb (filled symbols) and for the ipsilateral hindlimb (empty symbols) in rats administered riluzole (triangles) or glibenclamide (circles); 13 rats per group; data are shown as mean ± S.E; statistical significance was determined by non-parametric analysis; *P b 0.05; the abscissa gives the time in days (d) or weeks (w). In all cases, the drugs were administered beginning 3 h after impact and were continued for 1 week.