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. 2011 Dec 15;10(24):4208–4216. doi: 10.4161/cc.10.24.18487

Figure 2.

Figure 2

Onco-metabolites derived from the tumor stroma promote anabolic cancer cell growth via the TCA cycle and oxidative mitochondrial metabolism. Note that various stromally derived onco-metabolites (L-lactate, ketones, free fatty acids and glutamine; shown in red) all feed into the TCA/Krebs cycle via either Acetyl-CoA or Alpha-Keto-Glutarate, promoting oxidative mitochondrial metabolism (OXPHOS) in epithelial cancer cells. The end result is highly efficient ATP production in aggressive cancer cells.