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. 2011 Dec 15;10(24):4208–4216. doi: 10.4161/cc.10.24.18487

Figure 6.

Figure 6

Uncoupling parasitic cancer metabolism. Drugs such as chloroquine (which inhibits autophagy) and metformin (which inhibits lipolysis), will prevent energy transfer to cancer cells and tumor growth. In this scenario, mitochondrial poisons (such as metformin, arsenic and others) could also be used to uncouple tumor cells from the energy-producing host stroma.