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. 2011 Dec 15;10(24):4321–4329. doi: 10.4161/cc.10.24.18661

Figure 1.

Figure 1

Radiosensitization of pancreatic cancer cells in response to Chk1 and PARP1 inhibition. Representative radiation survival curves are shown for (A) MiaPaCa-2 and (B) MPanc-96 cell lines treated with AZD7762 (100 nM), olaparib (1 uM) and ionizing radiation (RT, 0–8 Gy) according to the illustrated schedule (D). Clonogenic survival plating efficiencies were 0.5 ± 0.1 (MiaPaCa-2) and 0.3 ± 0.1 (MPanc-96). Data are shown from a single representative experiment (A and B) or are the mean radiation enhancement ratio or cytotoxicity from n = 3 independent experiments ± SE. For (A and B), error bars are contained within the points. For (C), statistically significant differences (p < 0.05) are indicated vs. control (*), AZD7762 (†) and olaparib (‡).