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Model of SMARCAD1 function in chromatin replication: SMARCAD1 is recruited to replication sites by PCNA where it functions in a complex with KAP1, HDAC1, HDAC2 and the histone methyltransferase G9a/GLP. Deacetylation of newly assembled histones is facilitated by SMARCAD1 nucleosome remodeling and primes new nucleosomes for further modifications, promoting the inheritance of H3K9 methylation and the formation of heterochromatin.
