Table 1.

Selection of enriched Gene Ontology (GO) terms associated with Ascl1 target genes in ventral telencephalon of developing mouse embryo

GO Number	Biological Process	Genes	p value
GO:0045449	Regulation of transcription	69	1.8 × 10−8
GO:0022008	Neurogenesis	27	5.2 × 10−7
GO:0042136	Neurotransmitter biosynthetic process	3	9.2 × 10−5
GO:0051726	Regulation of cell cycle	11	9.6 × 10−5
GO:0010646	Regulation of cell communication	25	1.1 × 10−4
GO:0016337	Cell-cell adhesion	11	1.1 × 10−4
GO:0030030	Cell projection organization	17	1.2 × 10−4
GO:0009966	Regulation of signal transduction	22	1.8 × 10−4
GO:0006928	Cell motion	18	2.8 × 10−4
GO:0048663	Neuron fate commitment	6	2.8 × 10−4
GO:0007417	Central nervous system development	16	3.1 × 10−4
GO:0007411	Axon guidance	8	3.4 × 10−4
GO:0019226	Transmission of nerve impulse	13	4.0 × 10−4
GO:0007409	Axonogenesis	11	5.0 × 10−4
GO:0016568	Chromatin modification	12	5.2 × 10−4
GO:0007219	Notch signaling pathway	6	8.4 × 10−4
GO:0051960	Regulation of nervous system development	9	8.7 × 10−4
GO:0048667	Cell morphogenesis involved in neuron differentiation	11	8.8 × 10−4

Transcriptional profiling of Ascl1 gain- and loss-of-function, combined with genomic location analysis using ChIP-on-chip, was used to identify 339 direct Ascl1 trasncriptional targets.¹¹ Enriched terms describing biological processes were identified with GoToolbox,¹² using a hypergeometric distribution.