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Artemis interacts with p27. (A) Artemis interacts with p27 in vivo. Immunoblot analysis showing co-IP experiment performed in lysates from HEK293 cells. (B) Artemis directly interacts with p27 in vitro. GST, GST-Artemis, MBP and MBP-p27 were expressed in E. coli. Purified proteins were mixed and subjected to GST pull-down assays. (C) Putative structural model for the roles of DDB2 and Artemis in the ubiquitylation of p27 by the Cul4A-DDB1 complex.
