Skip to main content
. Author manuscript; available in PMC: 2013 Mar 20.
Published in final edited form as: Acc Chem Res. 2011 Sep 25;45(3):454–462. doi: 10.1021/ar200189b

Figure 2. Membrane disruption caused by IAPP variants in islet cells.

Figure 2

Disruption of the cellular membrane of intact islet cells causes an influx of extracellular calcium detected by the dye Fura-2AM localized in the cell. Human IAPP1–37, hIAPP1–19, and rIAPP1–19 cause a significant amount of influx immediately after addition (red line) while rIAPP1–37 does not, largely correlating with their ability to disrupt model membranes. The decrease in the signal after 250 seconds is most likely related to the escape of Fura-2 from the cell. Adapted from reference 17.