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. Author manuscript; available in PMC: 2013 Mar 20.
Published in final edited form as: Acc Chem Res. 2011 Sep 25;45(3):454–462. doi: 10.1021/ar200189b

Figure 3. Toxic variants of IAPP stabilize negative curvature.

Figure 3

(A) Cartoon of the inverted hexagonal phase, showing the highly curved surface around the lipid headgroup. (B) DSC chromatograms showing a significant lowering of the phase transition of DiPOPE to the inverted hexagonal phase for the toxic variants of IAPP (hIAPP1–37, hIAPP1–19, and rIAPP1–19) but not for the non-toxic rIAPP1–37, suggesting the ability to stabilize curvature of the membrane may be related to IAPP’s toxicity. Adapted from reference 19.