Fig. 1. HCV infection induces the production of various chemokines/cytokines in Huh7.5 cells stably reconstituted with functional TLR3 signaling.

Huh7.5 cells expressing the control vector (Vect), TLR3 or the indicated TLR3 mutant (H593E or N541A) were infected with JFH1 virus (MOI=0.2) for 3 days prior to measuring cytokine levels in culture supernatants by bioplex assay. “*” and “**” indicate statistical differences exist between mock- and HCV-infected 7.5-TLR3 cells with a p-value of <0.05 and <0.01, respectively. “◆” denotes p=0.13 between mock- and HCV-infected 7.5-TLR3 cells.