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Results from the initial siRNA screen in the HCT116 cells. The graphs show the relative toxicity, as assessed from MTT and toxilight assays, for all positive genes from the: (A) clinical analysis, (B) the 5-FU in vitro analysis, and (C) the SN38 in vitro analysis. Displayed are those genes that show an interaction between gene silencing and either 5-FU or SN38 treatment as measured by 2-way ANOVA. Synergistic interactions are highlighted as *=p<0.05, **=p<0.01 and ***=p<0.001.
