Skip to main content
. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2012 Feb;71(2):148–161. doi: 10.1097/NEN.0b013e318244477d

Figure 3.

Figure 3

Astrogliosis in regions of microinfarcts with evidence of severe respiratory chain deficiency in a patient with m.3243A>G. There are numerous microinfarcts in the cerebellar cortex (cresyl fast violet, [CFV)]); typically, these are accompanied by marked proliferation of glial fibrillary acidic protein (GFAP)-positive astrocytes (in a serial section). Evaluation of the mitochondrial proteins shows that mitochondrial density is reduced due to the necrosis (porin), but expression of complex I (subunits Cl-15 and -30) is completely absent; cytochrome c oxidase-1 (COX-I) is diminished. These observations suggest that astrocytes may also harbor respiratory-deficient mitochondria. Scale bar: 100 μm.