Table 3.
Percentage Level Heteroplasmy for Mutated or Deleted mtDNA
| Patient Number | Inferior olivary neurons | Purkinje cells | Dentate nucleus neurons |
|---|---|---|---|
| 1 | 93 ± 15.7 (n=11) | 90 ± 9.2 (n=15) | 77.5 ± 8.9 (n=6) |
| 4 | 88.3 ± 2.1 (n=4) | 80.8 ± 15.7 (n=11) | 73.3 ± 20.6 (n=12) |
| 6 | ND | 83.8 ± 3.8 (n=13) | 84.9 ± 11.1 (n=13) |
| 7 | ND | 91.7 ± 14.9 (n=13) | 86.4 ± 16.8 (n=20) |
| 8 | 86.1 ± 9.1 (n=8) | 91.9 ± 4 (n=13) | 87.4 ± 18.9 (n=17) |
| 9 | ND | 95 ± 9.6 (n=11) | 95.4 ± 5.7 (n=11) |
| 10 | 44.2 ± 18 (n=13) | 47.2 ± 21.2 (n=13) | 51.3 ± 19.1 (n=11) |
| 11 | 67.9 ± 11.9 (n=7) | 68.1 ± 9.4 (n=7) | 43.9 ± 6.8 (n=7) |
| 12 | ND | 19.9 ± 20 (n=10) | ND |
| 13 | ND | 50.7 ± 24 (n=21) | 24.9 ± 24.1 (n=21) |
| 14 | ND | 46.9 ± 31.3 (n=23) | ND |
Data are mean per cent ± SD; n = number of neurons laser-dissected and examined in each assay; ND = not determined.