Skip to main content
. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Free Radic Biol Med. 2011 Sep 29;52(2):247–256. doi: 10.1016/j.freeradbiomed.2011.09.016

Figure 3. Invadopodia NADPH oxidase complexes regulate redox signaling at invasive microdomains.

Figure 3

  1. Diagram of a cancer cell with invadopodia extending into the ECM substrate.
  2. Diagram showing the section of an invadopodium and the localization of NADPH oxidase complexes that mediate local generation of ROS (dots) to regulate invadopodia formation and activity.
  3. Specific NADPH oxidase complexes containing Tks4 and Tks5 proteins might be locally present at invadopodia. Question marks denote possible additional components of the invadopodia complex containing Nox4.