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. Author manuscript; available in PMC: 2013 Jan 15.
Published in final edited form as: Free Radic Biol Med. 2011 Sep 29;52(2):247–256. doi: 10.1016/j.freeradbiomed.2011.09.016

Figure 4. Model for a redox signaling pathway at invadopodia.

Figure 4

An active invadopodia NADPH oxidase complex containing a Tks protein family as an organizer generates ROS (dots) that locally amplify the tyrosine-phosphorylation signal initiated by Src-dependent phosphorylation of Tks proteins. The intensity and/or duration of the Tks tyrosine phosphorylation could be modulated by ROS through direct activation of Src or by inactivation of the phosphatase PTP-PEST, which may in turn dephosphorylate Src or Tks organizers. Dashed lines with question marks denote putative interactions.