Table 1.
Patient characteristics
| Variable | All (n = 29) |
ALI at enroll (n = 11) |
Developed ALI (n = 8) |
No ALI (n = 10) |
|---|---|---|---|---|
| Baseline characteristics | ||||
| Age, yrs | 63 ± 13 | 62 ± 10 | 61 ± 15 | 66 ± 16 |
| Male, n | 16 | 5 | 3 | 8 |
| Actual body weight , kga | 92.3 ± 28.4 | 102.8 ± 24.1 | 71.4 ± 14.6 | 97.4 ± 33.8 |
| Predicted body weight, kg | 63.6 ± 11.5 | 63.0 ± 11.0 | 62.1 ± 12.8 | 65.5 ± 11.8 |
| APACHE IIa | 28 ± 10 | 33 ± 9 | 23 ± 9 | 27 ± 9 |
| SAPS IIa | 60 ± 19 | 69 ± 20 | 51 ± 15 | 56 ± 16 |
| PEEP, cm H20c | 8 ± 3 | 10 ± 4 | 8 ± 2 | 6 ± 3 |
| Plateau pressure, cm H20 | 24 ± 8 | 25 ± 7 | 27 ± 9 | 22 ± 6 |
| Fluid balance, L | 12.1 ± 7.8 | 14.8 ± 10.6 | 12.1 ± 5.4 | 8.7 ± 2.3 |
| GEDI, ml/m2 | 786 ± 173 | 740 ± 177 | 813 ± 196 | 815 ± 155 |
| EVLWI, ml/kgb, c | 12.7 ± 5.7 | 14.3 ± 4.7 | 15.5 ± 7.4 | 8.7 ± 2.3 |
| PVPI b, c | 2.48 ± 1.51 | 2.72 ± 1.13 | 3.31 ± 2.19 | 1.57 ± 0.10 |
| VD/VT a, c | 0.63 ± 0.10 | 0.70 ± 0.08 | 0.61 ± 0.06 | 0.58 ± 0.10 |
| PaO2/FiO2 a,c | 244 ± 94 | 167 ± 59 | 322 ± 35 | 267 ± 98 |
| Static lung compliance/cm H2O | 37.6 ± 13.1 | 41.5 ± 13.6 | 30.9 ± 13.5 | 38.5 ± 11.7 |
| Diagnosis | ||||
| Sepsis, n (%) | 21 (72%) | 8 (73%) | 5 (63%) | 8 (80%) |
| Trauma, n (%) | 3 (10%) | 0 (0%) | 1 (13%) | 2 (20%) |
| Massive transfusion, n (%) | 4 (14%) | 2 (18%) | 1 (13%) | 1 (10%) |
| Massive aspiration, n (%) | 3 (10%) | 1 (9%) | 1 (13%) | 1 (10%) |
| Outcome | ||||
| ICU length of stay, days | 13 ± 7 | 14 ± 10 | 14 ± 5 | 10 ± 6 |
| Hospital length of stay, days | 21 ± 16 | 22 ± 19 | 27 ± 18 | 16 ± 8 |
| 28 day mortality, days | 10/29 (34 %) | 6/11 (55 %) | 1/8 (13 %) | 3/10 (30 %) |
Values are expressed as mean ± standard deviation or frequency (%) unless otherwise noted.
APACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; ALI, acute lung injury; GEDI, global end diastolic volume index; EVLWi, extravascular lung water indexed for predicted body weight; PVPI, pulmonary vascular permeability index; VD/VT, physiologic deadspace fraction; PaO2/FiO2, ratio of arterial partial pressure of oxygen to delivered oxygen fraction; ICU, intensive care unit.
p < .05 for those who had ALI at enrollment vs. those who developed ALI,
p < .05 for those who developed ALI vs. those who did not,
p < .05 for those had had ALI at enrollment vs. those who did not develop ALI.
Baseline characteristics represent the values obtained on study day 1.
Values are expressed as mean ± standard deviation or frequency (%) unless otherwise noted.
APACHE, Acute Physiology and Chronic Health Evaluation; SAPS, Simplified Acute Physiology Score; ALI, acute lung injury; GEDI, global end diastolic volume index; EVLWi, extravascular lung water indexed for predicted body weight; PVPI, pulmonary vascular permeability index; VD/VT, physiologic deadspace fraction; PaO2/FiO2, ratio of arterial partial pressure of oxygen to delivered oxygen fraction; ICU, intensive care unit.