Figure 6.

Effect of akt inhibitor viii (AKT I), rapamycin (RAP), vehicle (VEH) (phosphate-buffered saline, PBS), or combined treatment with RAP/AKT I (double inhibitor, DI) on Morris water maze (MWM) performance after sham injury or controlled cortical impact (CCI). (A) MWM performance did not differ between DI and VEH-treated, sham-injured mice (n=6/group). Following CCI, DI treatment significantly improved hidden platform performance (B) and probe trial scores (C) versus VEH (P=0.0011 for group, repeated measures analysis of variance (ANOVA), n=18/group). No significant differences were observed after CCI between single inhibitors (Akt inhibitor viii, n=20; RAP, n=12) and VEH groups in hidden platform (B) or probe trial (C) performance.