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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Med Primatol. 2011 Apr 4;40(5):300–309. doi: 10.1111/j.1600-0684.2011.00475.x

Table 1. Study summary.

Animal Study Inoculated CD8 depleted AIDS CNS Pathology CD4+/CD3+ count at day of sacrifice CD8 cells in the brain Scoring
meninges parenchyma
A03-053 Ctrl 1 N N N NSF N.D. ++ +
A03-054 Ctrl 2 N N N NSF N.D. ++ ++
A02-039 Ctrl 3 N N N NSF N.D. + +
A02-074 Ctrl 4 N N N NSF N.D. 0 +
A02-226 Ctrl 5 N N N NSF N.D. 0 +
A98-622 Ctrl 6 N N N NSF N.D. N.D. N.D.
A07-005 CD8- 1 N Y N NSF 1720/μL + ++
A07-006 CD8- 2 N Y N NSF 1039/μL 0 0
A07-207 CD8- 3 N Y N NSF 2193/μL + +
A07-208 CD8- 4 N Y N NSF 770/μL 0 +
A02-712 SIV+/CD8- 1 Y Y Y SIVE 1467/μL ++ ++
A02-743 SIV+/CD8- 2 Y Y Y SIVE 498/μL ++ +
A02-734 SIV+/CD8- 3 Y Y Y SIVE 958/μL ++ +
A02-746 SIV+/CD8- 4 Y Y Y SIVE 519/μL 0 +

NSF = no significant findings, N.D = Not determined.

CD8 + cells in the brain - scoring: 0 = no immunopositive cells observed in section; + = rare scattered cells;

Note that CD4 cells are artificially increased due to CD8-depletion and are therefore not useful for diagnosis of AIDS in the CD8-depleted macaque model of NeuroAIDS.