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SPR analysis of sulindac sulfide with immobilized Aβ42. Overlays of SPR sensorgrams obtained from injections of sulindac sulfide in 50mM sodium phosphate, 50mM NaCl, pH 7 with (A) No detergent, (B) 0.005% Tween-20, and (C) 0.2% Tween-20. Panel D shows corresponding sensorgrams of sulindac sulfone used as a negative control. Aβ42 was immobilized with ~3000 response units (RUs). Compounds at indicated concentration were injected for 55s at a flow rate of 30uL/min at 25 degrees C.
