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. 2012 Feb;11(2):119–128. doi: 10.1128/EC.05061-11

Fig 6.

Fig 6

Ser1074 and Ser1139 sites in Sak1. (A) Domain organization of Sak1. KD, kinase domain; NRD, N-terminal regulatory domain; CRD, C-terminal regulatory domain (57). Ser1074 (S1074) and Ser1139 (S1139) are located in the CRD. (B) The Ser1074 PKA motif is embedded in a box of sequence similarity present in Sak1 homologs of fungi representing several genera. Sc, Saccharomyces cerevisiae; Cg, Candida glabrata; Zr, Zygosaccharomyces rouxii; Lt, Lachancea thermotolerans; Ag, Ashbya gossipii. The amino acid positions of the key serine are indicated at the right. (C) Alignment of the Ser1139 site. Sc, S. cerevisiae; Sp, S. paradoxus; Sm, S. mikitae; Cg, C. glabrata. The amino acid positions of the key serine are indicated on the right. In panels B and C, the amino acid identities and similarities to the S. cerevisiae sequence are shaded black and gray, respectively.