Table 2.
Levels of antibodies in children with current parasitemia versus those who were aparasitemic in the subgroup of children who had previous episodes of malariaa
| Antigen | Antibody | Proportional difference in IgG levelsb | 95% CI | P value |
|---|---|---|---|---|
| MSP-119 | IgG | 1.61 | 1.24–2.09 | 0.0003 |
| IgG1 | 1.28 | 1.02–1.60 | 0.0332 | |
| IgG3 | 1.73 | 1.32–2.26 | <0.0001 | |
| AMA-1 | IgG1 | 1.44 | 1.12–1.85 | 0.0044 |
| IgG3 | 1.82 | 1.37–2.42 | <0.0001 | |
| IgG4 | 1.11 | 1.02–1.22 | 0.0222 | |
| EBA-175 | IgG3 | 1.46 | 1.15–1.86 | 0.0020 |
a
Current infection was significantly associated with increased antibody levels for the antigens and IgG isotypes included in the table. The analysis was done by multivariate random-effect regression models using a forward stepwise procedure (P-enter = 0.05, from likelihood ratio test) including the following variables: intervention group, age, number of previous malaria episodes, time from previous episodes, current infection, and parasite density.
b
Difference in IgG levels in children who were currently parasitemic versus those who were not.