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Regulation of caspase 7 cleavage of YY1 by CK2α. The model represents how YY1, a caspase substrate, is protected from caspase 7 cleavage when it is phosphorylated at S118 by CK2α. S118 is a residue adjacent to the caspase 7 recognition site. Failure of YY1 to undergo caspase cleavage in response to apoptotic signals could contribute to tumorigenesis.
