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. 2011 Dec 20;106(3):475–481. doi: 10.1038/bjc.2011.564

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Copyright © 2012 Cancer Research UK

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BPR1J-097 inhibits FLT3-dependent signalling. (A) HEK 293T cells were transfected with FLT-WT-, FLT3-ITD-, or FLT3-D835Y-expressing plasmids for 24 h and then incubated with various concentrations of BPR1J-097 for 2 h. (B) MV4-11 cells, which are homozygous for FLT-ITD, were treated with BPR1J-097 at the indicated concentrations for 2 h. The phosphorylation states of FLT3 and STAT5 were evaluated by western blot.