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. 2011 Dec 2;31(3):593–605. doi: 10.1038/emboj.2011.431

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Copyright © 2012, European Molecular Biology Organization

This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial No Derivative Works 3.0 Unported License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.

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Responsiveness of PRC2 recruitment to presence of NuRD. (A) Western blot of nuclear extracts prepared from wild-type, Mbd3^−/− and MER-Mbd3b-MER Mbd3^−/− cells after addition of 4-hydroxytamoxifen for indicated time. Alpha tubulin acts as a loading control. (B) Expression levels of Htra1 in wild-type, Mbd3^−/− and MER-Mbd3b-MER Mbd3^−/− cells over the indicated 4-hydroxytamoxifen time course relative to Mbd3^−/− levels. (C) Occupancy levels for H3K27ac, H3K27me3, Jarid2 and Mer-Mbd3b-MER at the Htra1 locus over the 4-hydroxytamoxifen time course in MER-Mbd3b-MER Mbd3^−/− ES cells. Levels are shown relative to highest point for each protein.