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. 2011 Nov 29;31(3):754–766. doi: 10.1038/emboj.2011.429

Figure 9.

Figure 9

Model for recruitment of PI4KB to the AiV replication sites. In uninfected cells, the C-terminal region of ACBD3 binds to the C-terminal cytoplasmic domain of giantin that is anchored to the Golgi membrane through the C-terminal anchoring domain. PI4KB is localized to the Golgi through interaction with the central part of ACBD3 (left panel). In AiV-infected cells, viral membrane proteins 2B, 2BC, 2C, 3A, and 3AB compete with giantin at the Golgi for binding to ACBD3. The viral protein/ACBD3/PI4KB complex is formed as infection progresses, whereas giantin no longer colocalizes with ACBD3 (right panel).